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Harmine - DYRK1A Inhibitor. CAS# 442-51-3 size:10 mg solid OAC1 seems to enhance reprogramming

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Description

OAC1 seems to enhance reprogramming efficiency in a unique manner

Grembecka J

Bioymifi is capable of acting as a single agent to induce DR5 clustering and aggregation

MTH1 is a nucleotide pool sanitizing enzyme

Chemical Name: 1-(3

Harmine - DYRK1A Inhibitor. CAS# 442-51-3 size:10 mg solid OAC1 seems to enhance reprogrammingHarmine, CAS No. 442 51 3, is a potent, selective and orally bioavailable DYRK1A inhibitor with IC50 of 80 nM. It inhibits phosphorylation of tau directly by DYRK1A (IC50 ~700 nM). It has >10 fold selectivity over DYRK3 and DYRK2 (IC50 ~800 nM and 900 nM respectively. Harmine is also a unique regulator of PPAR expression that acts by inhibiting the Wnt signalling pathway in a cell specific manner. It attenuates inflammatory gene expression (TNF, IL 1,

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